Basic Information

Symbol
RBM3
RNA class
mRNA
Alias
RNA Binding Motif Protein 3 IS1-RNPL RNA-Binding Protein 3 RNPL RNA Binding Motif (RNP1, RRM) Protein 3 RNA-Binding Motif Protein 3
Location (GRCh38)
X:48574056-48581162
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006743.5
Sequence length
4298.0 nt
GC content
0.4597

Transcripts

ID Sequence Length GC content
NM_006743.5 NCBI
AUCAAUCGUCUUCCGGCGCAGCCCCGUCCCUGUUUUUUGUGCUCCUCCG… 4298 nt 0.4597
Summary

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the cold shock protein RBM3 showed significantly higher expression in neurocytes, alveolar epithelial cells, and renal tubular epithelial cells of a fatal hypothermia case compared to a trauma control, while its expression was lower in myocardial cells, suggesting its potential as an auxiliary diagnostic indicator for fatal hypothermia in forensic medicine [Zheng et al. DOI:10.1016/J.Jflm.2024.102786].