Basic Information

Symbol
RBM45
RNA class
mRNA
Alias
RNA Binding Motif Protein 45 DRB1 RNA-Binding Protein 45 FLJ44612 RB-1 Developmentally Regulated RNA Binding Protein 1 Developmentally Regulated RNA-Binding Protein 1 Developmentally-Regulated RNA-Binding Protein 1 Putative RNA Binding Protein RB-1 RNA-Binding Motif Protein 45 DRBP1
Location (GRCh38)
2:178112385-178139011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_152945.4
Sequence length
1803.0 nt
GC content
0.4359

Transcripts

ID Sequence Length GC content
NM_001365578.1 NCBI
CUCCCGGAAGCGGAGCACCGAGCCGGCAAAGGCUUGGGUGUGAGACAGC… 1841 nt 0.4340
NM_001365579.1 NCBI
CUCCCGGAAGCGGAGCACCGAGCCGGCAAAGGCUUGGGUGUGAGACAGC… 1809 nt 0.4367
NM_152945.4 NCBI
CUCCCGGAAGCGGAGCACCGAGCCGGCAAAGGCUUGGGUGUGAGACAGC… 1803 nt 0.4359
Summary

This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

Forensic Context

A study in mice demonstrated that the RBM45 transcript, a brain development RNA-binding protein, increased in relative abundance within 0.5 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].