Basic Information

Symbol
RBMY1A1
RNA class
mRNA
Alias
RNA Binding Motif Protein Y-Linked Family 1 Member A1 YRRM1 YRRM2 RBM1 RBM2 RNA-Binding Motif Protein, Y Chromosome, Family 1 Member A1 Y Chromosome RNA Recognition Motif 1 RNA-Binding Motif Protein 2 RNA-Binding Motif Protein, Y Chromosome, Family 1 Member A1/C RNA Binding Motif Protein, Y Chromosome, Family 1, Member A1 RNA Binding Motif Protein, Y-Linked, Family 1, Member A1 Y Chromosome RNA Recognition Motif 2 RNA-Binding Motif Protein 1 RBMY1C HRBMY RBMY RBM
Location (GRCh38)
Y:21534879-21549326
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005058.4
Sequence length
1921.0 nt
GC content
0.4394

Transcripts

ID Sequence Length GC content
NM_001320944.2 NCBI
AUUUCCGGGCACGGCUUCCGGCGUCCUUCCCUCUCAGGGAAGCUCCAGC… 1810 nt 0.4403
NM_001320945.2 NCBI
AUUUCCGGGCACGGCUUCCGGCGUCCUUCCCUCUCAGGGAAGCUCCAGC… 1743 nt 0.4337
NM_005058.4 NCBI
AUUUCCGGGCACGGCUUCCGGCGUCCUUCCCUCUCAGGGAAGCUCCAGC… 1921 nt 0.4394
Summary

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]

Forensic Context

A study in mice demonstrated that radiation-induced gastric injury from 6 or 12 Gy X-ray exposure caused atrophy and abnormal cell morphology, accompanied by increased serum pepsinogen A and C levels and widespread dysregulation of mRNAs and lncRNAs [Chen et al. DOI:10.1177/1559325819886766].