Basic Information

Symbol
RBP4
RNA class
mRNA
Alias
Retinol Binding Protein 4 Plasma Retinol-Binding Protein Retinol-Binding Protein 4 PRBP RBP Retinol-Binding Protein 4, Interstitial Retinol-Binding Protein 4, Plasma Retinol Binding Protein 4, Plasma MCOPCB10 RDCCAS
Location (GRCh38)
10:93590170-93603110
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006744.4
Sequence length
1070.0 nt
GC content
0.5486

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-366.50 kcal/mol
Thermodynamic ensemble
Free energy: -386.07 kcal/mol
Frequency: 0.0000
Diversity: 325.68
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((..(((.......)))...)))...)))((((((((......(((((((((((.(((((((((((..(((((((.((.(((((((((.(((.(((((...(((((((((((((((((..((.(((((((((...)))))...))))..))..))))......((((((.....))).)))..(((((((((((((.((.(((((....))).)))).)))(((.(((...))))))...(((((.(.(((....((((.(((.((((.....(((((.((((((((...((.((......))))..))))).))))))))...))))..))).))))))).))))))..(((((((..((((..........))))..)))))))(.((((...)))).)...)))))).))))(((((((....)))))))...(((((((...)).)))))......((.(((..((((.....))))..))).))..))))))...........)))))))...))))).))).)))))...)))).))..)))))))..))....))))))).......((((.............)).)))).))).))))))))))))))))(((((.((((((((((((((.....)))))).((((....)))).(((((((((....(((((((....)).)))))............((((((.((.......)).)))))).....((((((..........))))))......((((......(((((((((((................................(((((((.(((((((((.(.((((((....(((...((.(((...))).)))))...))))))).))))))........((((((.((((((.........)))))).)))))).))).)))))))..((((((...))))))))).)))))))).(.((((((.......)))))).)).)))))))))))).....)))))))...).)))))...................(((......))).
Thermodynamic Ensemble Prediction
((((((..(((.....}})})...))}...)))((((((((,,{{{((((({((({{(,(((({((({((,,(({{{(({,,.{{{,,{(((.(((.(((((,,.{(((((((((({((((.(((((,,{,(((,,...))))}.))))).)))|,{||||.,{{,,(((,{({,{,.|||{|,,..||}}|}|||||||.(|,{{{((,.,,}}},|}}}{{{|{((.(((...))))))))}{((((.{,{{,...,((((,(((,{{{{,}}},|||||,{{||||||,,.,|,||,,,,,,})))..})))),))))))))...},,,..)))}))}})))}))))}|{.(((((((..((((..........))))..))))))).}}||...,,|,|{{{{{{{{{({,,|}}(((((((....)))))))..,(((((((...)).))))),...,.|.,{{{{.,,||}}..,}))|||||,||{{{|||||,.{{{...,,..}}}))}}.,,||}}}.))),}}}},.{{||||{||{,},}|||,,{|,...}),||||}}...}}}}|}}.},}}..,,,.,)),.))))})))})}})))))))))))))(((((.{(((((((((((((.....)))))).((((....)))).(((((((((..{,,,{{(,,....,,.}}}||{....,.},,..((((((.((.......)).)))))).....{(((((.........,)))))}......||{,....,.(((((((({((....{,..................,.,,{,,,{(({{{{.(({((((((.(.((((((....(((,..{(.((,...,)).)))))...))))))).)))))).},.....((((((.((((((.........)))))).)))))).},}.))))))}.,|(((({...)))))}))).)))))))).{.((((((.......)))))).}}.)),))))))))).....)))))))...}.)))))...................|||,.....,,..

Transcripts

ID Sequence Length GC content
NM_001323517.1 NCBI
GGCGGCCGCUGGCACGAGUGCAGGGUAACUGAGCCAGGGCCGCUGGCGC… 1015 nt 0.5783
NM_001323518.2 NCBI
AUCCUUUAUAAAAUGAAAAACUACUUGGAUGAAUUAUUCCAAAAUUCCU… 1009 nt 0.5074
NM_006744.4 NCBI
GCCUCCCUCGCUCCACGCGCGCCCGGACUCGGCGGCCAGGCUUGCGCGC… 1070 nt 0.5486
Summary

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the RBP4 was characteristically down-regulated in the liver following in vivo exposure to α-particles, specifically from Kupffer cell and endothelial cell irradiation, as well as from neutron and γ-ray exposures, compared to non-irradiated controls [Roudkenar et al. DOI:10.1269/jrr.07078].