Basic Information

Symbol
RBPJ
RNA class
mRNA
Alias
Recombination Signal Binding Protein For Immunoglobulin Kappa J Region IGKJRB RBPJK RBP-J IGKJRB1 RBPSUH KBF2 CBF1 SUH Recombining Binding Protein Suppressor Of Hairless Renal Carcinoma Antigen NY-REN-30 CSL Family DNA Binding Factor 1 RBP-J Kappa RBP-JK CBF-1 Immunoglobulin Kappa J Region Recombination Signal Binding Protein 1 Recombining Binding Protein Suppressor Of Hairless (Drosophila) J Kappa-Recombination Signal-Binding Protein Suppressor Of Hairless Homolog (Drosophila) Suppressor Of Hairless Homolog H-2K Binding Factor-2 AOS3 Csl
Location (GRCh38)
4:26163455-26435131
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015874.6
Sequence length
5395.0 nt
GC content
0.3720

Transcripts

ID Sequence Length GC content
NM_001363577.2 NCBI
GCCGUGGCUCAGGCUCCAGCGCGUGAGGGCGGGCGGCGGCGGCGGCGGC… 6212 nt 0.3983
NM_001374400.1 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGUCUCCACGUACGUCCCUCAAAGCG… 5709 nt 0.3747
NM_001374401.1 NCBI
AUUCUGACAUUUUUACUUCCUUUGUUGCCAGGCAAAGUGGCCACCAGAU… 5908 nt 0.3702
NM_001374402.1 NCBI
GCCGUGGCUCAGGCUCCAGCGCGUGAGGGCGGGCGGCGGCGGCGGCGGC… 5811 nt 0.3731
NM_001374403.1 NCBI
GUGUUUGUUAUUGUGAAUCCCUAAGGGUGACUGUUUUUUCAGCAGGGCG… 5835 nt 0.3692
NM_001379406.1 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… 5894 nt 0.3734
NM_001379407.1 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… 6010 nt 0.3792
NM_001379408.1 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… 5671 nt 0.3765
NM_001379409.1 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… 5555 nt 0.3703
NM_005349.4 NCBI
GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… 5827 nt 0.3791
Showing 1 to 10 of 13 entries
Summary

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

Forensic Context

No relevant information is available at the moment.