Basic Information
Symbol
RBPJ
RNA class
mRNA
Alias
Recombination Signal Binding Protein For Immunoglobulin Kappa J Region
IGKJRB
RBPJK
RBP-J
IGKJRB1
RBPSUH
KBF2
CBF1
SUH
Recombining Binding Protein Suppressor Of Hairless
Renal Carcinoma Antigen NY-REN-30
CSL Family DNA Binding Factor 1
RBP-J Kappa
RBP-JK
CBF-1
Immunoglobulin Kappa J Region Recombination Signal Binding Protein 1
Recombining Binding Protein Suppressor Of Hairless (Drosophila)
J Kappa-Recombination Signal-Binding Protein
Suppressor Of Hairless Homolog (Drosophila)
Suppressor Of Hairless Homolog
H-2K Binding Factor-2
AOS3
Csl
Location (GRCh38)
4:26163455-26435131
Forensic tag(s)
-
MANE select
Transcript ID
NM_015874.6
Sequence length
5395.0 nt
GC content
0.3720
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GAGAGUUUGUGGAAGAUGGCGCCUGUUGUGACAGGGAAAUUUGGUGAGC… | 5395 nt | 0.3720 | |
| GCCAAUCCUGCAGCGCCUUCAACAGGUUUCGGGCGGCGAAUUCCAGUUC… | 5711 nt | 0.3731 | |
| GAGAGUUUGUGGAAGAUGGCGCCUGUUGUGACAGGUCAUUGAAAUUAUG… | 5786 nt | 0.3690 |
Showing 11 to 13 of 13 entries
Summary
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Forensic Context
No relevant information is available at the moment.