Basic Information

Symbol
RBX1
RNA class
mRNA
Alias
Ring-Box 1 RNF75 ROC1 Regulator Of Cullins 1 BA554C12.1 E3 Ubiquitin-Protein Transferase RBX1 E3 Ubiquitin-Protein Ligase RBX1 RING Finger Protein 75 RING-Box Protein 1 Ring-Box 1, E3 Ubiquitin Protein Ligase ZYP Protein Protein ZYP EC 2.3.2.27 EC 2.3.2.32 Rbx1
Location (GRCh38)
22:40951277-40973539
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014248.4
Sequence length
1169.0 nt
GC content
0.4790

Transcripts

ID Sequence Length GC content
NM_014248.4 NCBI
GACAGACCGUGUGUUUCCAAAAUGGCGGCAGCGAUGGAUGUGGAUACCC… 1169 nt 0.4790
Summary

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

Forensic Context

A longitudinal mRNA expression analysis in post-mortem human blood samples demonstrated that the RBX1 (RBX1), a protein-coding gene involved in nucleotide-excision repair, shows an up-regulated expression pattern after death and was identified as a biomarker for post-mortem interval (PMI) estimation [Antiga et al. DOI:10.1038/s41598-021-96095-z].