Basic Information

Symbol
RC3H2
RNA class
mRNA
Alias
Ring Finger And CCCH-Type Domains 2 RNF164 Roquin-2 MNAB Membrane-Associated Nucleic Acid-Binding Protein Ring Finger And CCCH-Type Zinc Finger Domains 2 RING-Type E3 Ubiquitin Transferase Roquin-2 Membrane Associated DNA Binding Protein RING Finger Protein 164 FLJ20301 FLJ20713 Ring Finger And CCCH-Type Zinc Finger Domain-Containing Protein 2 RING Finger And CCCH-Type Zinc Finger Domain-Containing Protein 2 EC 2.3.2.27
Location (GRCh38)
9:122844556-122905513
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001100588.3
Sequence length
8964.0 nt
GC content
0.3919

Transcripts

ID Sequence Length GC content
NM_001100588.3 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 8964 nt 0.3919
NM_001354478.2 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 8945 nt 0.3918
NM_001354479.2 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 8793 nt 0.3900
NM_001354482.2 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 8850 nt 0.3921
NM_001354486.2 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 3225 nt 0.4353
NM_018835.5 NCBI
AUCCCUCCAGGUCCGCCUCCGUGGUGAGGAGGAGGAGGAGGAGGAGGCG… 3592 nt 0.4633
Summary

Enables DNA binding activity; RNA binding activity; and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Located in cell surface; intracellular membrane-bounded organelle; and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans identified the RC3H2 as an important gene in a lasso regression model for age prediction using RNA-Seq data from whole blood, where it had a positive coefficient in the model derived from a U.S. data set [Dørum et al. DOI:10.1016/j.fsigen.2023.102976]. This lasso-selected gene list demonstrated a mean absolute error of 4.35 years for age prediction on that data set, indicating its utility within a multi-marker panel for forensic age estimation from blood stains.