Basic Information

Symbol
RCHY1
RNA class
mRNA
Alias
Ring Finger And CHY Zinc Finger Domain Containing 1 RNF199 ZNF363 CHIMP ARNIP PIRH2 PRO1996 ZCHY RING Finger And CHY Zinc Finger Domain-Containing Protein 1 Androgen-Receptor N-Terminal-Interacting Protein P53-Induced Protein With A RING-H2 Domain RING-Type E3 Ubiquitin Transferase RCHY1 E3 Ubiquitin-Protein Ligase Pirh2 RING Finger Protein 199 Zinc Finger Protein 363 Zinc Finger, CHY-Type DKFZp586C1620 Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Androgen Receptor N-Terminal-Interacting Protein CH-Rich Interacting Match With PLAG1 CH-Rich-Interacting Match With PLAG1 P53-Induced RING-H2 Protein EC 2.3.2.27 HPirh2
Location (GRCh38)
4:75479033-75514764
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015436.4
Sequence length
4408.0 nt
GC content
0.3555

Transcripts

ID Sequence Length GC content
NM_001009922.3 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4381 nt 0.3559
NM_001278536.2 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4288 nt 0.3547
NM_001278537.2 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4261 nt 0.3551
NM_001278538.2 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4364 nt 0.3533
NM_001278539.2 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4446 nt 0.3572
NM_001387136.1 NCBI
CCCUUUCUCCAGGCUCCCCGCCACCGGAGGGAGAGAGGGAGGACCCGUC… 4250 nt 0.3466
NM_001387137.1 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4404 nt 0.3554
NM_015436.4 NCBI
AUAUUGUCGCUAGUGGCCGCUGGGGCUGGGAGGGGUGUGCUAGAGAGGC… 4408 nt 0.3555
Summary

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the RCHY1 in cortical microglia, as part of widespread alterations in the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].