Basic Information

Symbol
RCVRN
RNA class
mRNA
Alias
Recoverin RCV1 Cancer-Associated Retinopathy Protein Cancer Associated Retinopathy Antigen Protein CAR
Location (GRCh38)
17:9896320-9905271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002903.3
Sequence length
2469.0 nt
GC content
0.5537

Transcripts

ID Sequence Length GC content
NM_002903.3 NCBI
ACACCAGCCUUGAGCCCAGCCUGCGGCCAGGGGACCACGCACGUCCCAC… 2469 nt 0.5537
Summary

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human neonates with hypoxic-ischemic encephalopathy (HIE) demonstrated that the RCVRN was a top differentially expressed gene associated with adverse outcome (death or disability) in the high-income country cohort, showing significant upregulation (log2 fold change, 2.84) and association with hypoxia-induced retinogenesis and HIF-1α signaling [Montaldo et al. DOI:10.1001/jamanetworkopen.2023.54433].