Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 2663 nt | 0.4318 | |
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 2371 nt | 0.4365 | |
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 4021 nt | 0.3725 | |
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 1716 nt | 0.4598 | |
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 1451 nt | 0.4549 | |
| AUAUUGCGGAGCUGUCUGCGGUGGCGGCGGCGCCUCUCGUCUCCCGCGG… | 4392 nt | 0.3743 |
Summary
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Forensic Context
A study in *Chrysomya megacephala* larvae demonstrated that the gene encoding the RDX was significantly up-regulated in larvae fed soybean oil or lard oil compared to a negative control, as identified through digital gene expression profiling and validated by RT-PCR and qRT-PCR [Zhang et al. DOI:10.1371/journal.pone.0063168]. A study in human keratinocytes and mouse skin demonstrated that the RDX was downregulated (0.66-fold) following 5 Gy X-ray irradiation, as identified via cDNA microarray analysis [Koike et al. DOI:10.1269/jrr.46.173].