Basic Information

Symbol
REEP5
RNA class
mRNA
Alias
Receptor Accessory Protein 5 DP1 TB2 Polyposis Locus Protein 1 C5orf18 D5S346 Yip2e POB16 Polyposis Coli Region Hypothetical Protein DP1 Receptor Expression-Enhancing Protein 5 Deleted In Polyposis 1 Chromosome 5 Open Reading Frame 18 Protein TB2 YOP1
Location (GRCh38)
5:112876385-112922328
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005669.5
Sequence length
3008.0 nt
GC content
0.3826

Transcripts

ID Sequence Length GC content
NM_005669.5 NCBI
ACUAGGAACAGCCCCGAGCGGCGAGACGGUCCCCGCCAUGUCUGCGGCC… 3008 nt 0.3826
Summary

Predicted to be involved in endoplasmic reticulum membrane organization and regulation of intracellular transport. Located in endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans identified the REEP5 as a housekeeping gene with highly uniform and strong expression across 16 normal tissues, proposing it for calibration in biotechnological applications [Eisenberg & Levanon DOI:10.1016/j.tig.2013.05.010]. Subsequent research in mice with sepsis found that the mRNA expression level of the REEP5 did not show a significant difference between cecal ligation and puncture and sham control groups [Yang et al. DOI:10.1038/s41598-025-06463-2]. A study in rats demonstrated that the REEP5 was differentially expressed in the hypothalamus during hypothermia, with 18 tags in control samples versus 4 tags in hypothermic samples, indicating its downregulation in the hypothermic state [Takamiya et al. DOI:10.1016/J.Jflm.2012.04.017]. In a separate human study, the REEP5 was identified as a housekeeping gene with highly uniform and strong expression across 16 normal tissues, leading to its proposal as a calibration control for genomic studies [Eisenberg and Levanon DOI:10.1016/j.tig.2013.05.010].