Basic Information

Symbol
REG3A
RNA class
mRNA
Alias
Regenerating Family Member 3 Alpha PAP1 HIP REG-III PBCGF REG3 PAP Regenerating Islet-Derived Protein III-Alpha Regenerating Islet-Derived Protein 3-Alpha Hepatointestinal Pancreatic Protein Regenerating Islet-Derived 3 Alpha Pancreatitis-Associated Protein 1 Human Proislet Peptide Reg III-Alpha REG-3-Alpha HIP/PAP Hepatocarcinoma-Intestine-Pancreas Pancreatic Beta Cell Growth Factor Proliferation-Inducing Protein 34 Proliferation-Inducing Protein 42 Pancreatitis-Associated Protein PAP Homologous Protein INGAP PAP-H
Location (GRCh38)
2:79157003-79159753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002580.3
Sequence length
808.0 nt
GC content
0.5161

Transcripts

ID Sequence Length GC content
NM_002580.3 NCBI
AAACCAUACCAUAUCCCACCAGAGAGUGACUCCUGAUUGCCUCCUCAAG… 808 nt 0.5161
NM_138937.3 NCBI
AAACCAUACCAUAUCCCACCAGAGAGUCGCAGACACUAUGCUGCCUCCC… 785 nt 0.5159
NM_138938.3 NCBI
AAACCAUACCAUAUCCCACCAGAGAGGUAAGUGGGAGCUGAGAGAAGAU… 1096 nt 0.5155
Summary

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

Forensic Context

A study in humans demonstrated that prostatic acid phosphatase protein, detected via the SM-test reagent, remained a reliable forensic marker for semen identification in extremely aged seminal stains stored at room temperature for 33 to 56 years, with all aged samples testing positive [Nakanishi et al. DOI:10.1016/j.legalmed.2014.04.002].