Basic Information

Symbol
RELA
RNA class
mRNA
Alias
RELA Proto-Oncogene, NF-KB Subunit Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 NFKB3 P65 V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A Nuclear Factor NF-Kappa-B P65 Subunit Transcription Factor P65 NF-Kappa-B Transcription Factor P65 NF-Kappa-B P65delta3 AIF3BL3 CMCU
Location (GRCh38)
11:65653599-65663090
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021975.4
Sequence length
2517.0 nt
GC content
0.5860

Transcripts

ID Sequence Length GC content
NM_001145138.2 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2508 nt 0.5869
NM_001243984.2 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2310 nt 0.5810
NM_001243985.2 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2208 nt 0.5797
NM_001404657.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2550 nt 0.5851
NM_001404658.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2490 nt 0.5859
NM_001404659.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2304 nt 0.5833
NM_001404660.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2199 nt 0.5839
NM_001404661.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2425 nt 0.5876
NM_001404662.1 NCBI
AGCCUCCACACGGACGCGCCUUGGGCUUGGUCUUGGGGGAGCUACCUGC… 3114 nt 0.5931
NM_001404663.1 NCBI
AUUUCCGCCUCUGGCGAAUGGCUCGUCUGUAGUGCACGCCGCGGGCCCA… 2659 nt 0.5859
Showing 1 to 10 of 11 entries
Summary

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Forensic Context

A study in mice demonstrated that the transcription factor RELA was a key prognosis-related regulator in sepsis-associated acute kidney injury, where its target genes were significantly enriched among downregulated genes in the recovery group [Yang et al. DOI:10.3892/etm.2020.9161]. In human post-mortem tissues, the RELA gene was differentially expressed as part of non-canonical NF-κB signaling mediated by Dectin-1 in the heart and colon during septic shock [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938]. A study in mice demonstrated that sepsis-induced myocardial injury from cecal ligation and puncture (CLP) led to increased phosphorylation of the RELA at Ser536, indicating NF-κB pathway activation, which was attenuated by treatment with the PI3Kγ-specific inhibitor CZC24832, thereby improving cardiac function and survival [Yan et al. DOI:10.3389/fphys.2022.903164].