Basic Information

Symbol
RELB
RNA class
mRNA
Alias
RELB Proto-Oncogene, NF-KB Subunit REL-B V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3) Transcription Factor RelB V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 I-REL IMD53 I-Rel IREL
Location (GRCh38)
19:45001461-45038192
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006509.4
Sequence length
2258.0 nt
GC content
0.6492

Transcripts

ID Sequence Length GC content
NM_001411087.1 NCBI
GCAGCCCCGGGCGCCGCGCGUCCUGCCCGGCCUGCGGCCCCAGCCCUUG… 2249 nt 0.6505
NM_006509.4 NCBI
GCAGCCCCGGGCGCCGCGCGUCCUGCCCGGCCUGCGGCCCCAGCCCUUG… 2258 nt 0.6492
Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans analyzing single-cell and bulk RNA-sequencing data from sepsis patients identified the IL-17 signaling pathway as a key mechanism, with pathway-associated genes including the RELB being significantly up-regulated in sepsis blood samples and specific T cell subsets compared to healthy controls [Zhao et al. DOI:10.1016/j.imbio.2023.152763].