Basic Information

Symbol
REPS2
RNA class
mRNA
Alias
RALBP1 Associated Eps Domain Containing 2 POB1 RalBP1-Associated Eps Domain-Containing Protein 2 Partner Of RalBP1 Partner Of Ral-Binding Protein 1 RALBP1-Interacting Protein 2 RalBP1-Interacting Protein 2
Location (GRCh38)
X:16946658-17153272
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004726.3
Sequence length
7978.0 nt
GC content
0.4347

Transcripts

ID Sequence Length GC content
NM_001080975.2 NCBI
AACAUUCAAGCCCGGGGGUGGGGCCGGCGCGCGCCGGGAGGAAGCGGCC… 7975 nt 0.4346
NM_004726.3 NCBI
AACAUUCAAGCCCGGGGGUGGGGCCGGCGCGCGCCGGGAGGAAGCGGCC… 7978 nt 0.4347
Summary

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans established a targeted RNA sequencing protocol for predicting the time-of-day of bloodstain deposition using 69 candidate mRNA markers, where the REPS2 was excluded from the final Refall-normalised dataset after initial evaluation due to high correlation with other markers [Gosch et al. DOI:10.1101/2025.02.03.636230][Gosch et al. DOI:10.1016/J.Fsigen.2025.103287].