Basic Information

Symbol
REST
RNA class
mRNA
Alias
RE1 Silencing Transcription Factor NRSF XBR RE1-Silencing Transcription Factor Neural-Restrictive Silencer Factor DFNA27 Neuron-Restrictive Silencer Factor Neuron Restrictive Silencer Factor Deafness, Autosomal Dominant 27 Repressor Binding To The X2 Box X2 Box Repressor GINGF5 HGF5 WT6
Location (GRCh38)
4:56907876-56966808
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005612.5
Sequence length
7309.0 nt
GC content
0.4002

Transcripts

ID Sequence Length GC content
NM_001193508.1 NCBI
CGGCGCUCGGAGCCCGACGCCUCGCGAGGGCGCCCGCGGAGCCUCCCCG… 7122 nt 0.3943
NM_001363453.2 NCBI
ACAGCGAUUUCUGCGCUUCAGCCGUCCGGCGCCGCUGGCCCCCGCGUCC… 7841 nt 0.4151
NM_005612.5 NCBI
GUGCGCGGCGCAGCGUCCUGUGUUGGAAUGUGCGGCUGCCGCGAGCUCG… 7309 nt 0.4002
Summary

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

Forensic Context

A study in mice demonstrated that ethanol exposure increased the expression of the REST mRNA, an effect also observed following siRNA-mediated knockdown of the mOct4pg9 ncRNA [Salem et al. DOI:10.1016/J.Ntt.2020.106943].