Basic Information

Symbol
RETN
RNA class
mRNA
Alias
Resistin FIZZ3 ADSF RETN1 C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Cysteine-Rich Secreted Protein A12-Alpha-Like 2 Adipose Tissue-Specific Secretory Factor Cysteine-Rich Secreted Protein FIZZ3 RSTN C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 1 Found In Inflammatory Zone 3 Resistin Delta2 HXCP1 RENT XCP1
Location (GRCh38)
19:7669049-7670455
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020415.4
Sequence length
516.0 nt
GC content
0.6221

Transcripts

ID Sequence Length GC content
NM_001193374.2 NCBI
AAGAGGCCUCAAAGAAAGAGCUGCGGUGCAGGAAUUCGUGUGCCGGAUU… 507 nt 0.6193
NM_001385725.1 NCBI
AAGAGGCCUCAAAGAAAGAGCUGCGGUGCAGGAAUUCGUGUGCCGGAUU… 560 nt 0.6196
NM_001385726.1 NCBI
AAGAGGCCUCAAAGAAAGAGCUGCGGUGCAGGAAUUCGUGUGCCGGAUU… 558 nt 0.6254
NM_001385727.1 NCBI
AAGAGGCCUCAAAGAAAGAGCUGCGGUGCAGGAAUUCGUGUGCCGGAUU… 438 nt 0.6256
NM_020415.4 NCBI
AAGAGGCCUCAAAGAAAGAGCUGCGGUGCAGGAAUUCGUGUGCCGGAUU… 516 nt 0.6221
Summary

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]

Forensic Context

A study in humans demonstrated that the RETN (RETN) is a core biomarker for sepsis, showing strong positive correlation and significantly higher expression in sepsis patients compared to healthy controls [Wang et al. DOI:10.2147/IDR.S380137]. Further research confirmed its diagnostic and prognostic value, with higher expression levels linked to an increased mortality risk, and single-cell RNA sequencing localized its expression primarily to monocytes, neutrophils, and macrophage cell lines [Li et al. DOI:10.3389/fimmu.2025.1700704]. A study in mice demonstrated that thermal injury induces significant increases in the RETN gene expression in gonadal adipose tissue and serum protein levels, which peaked at 24 and 48 hours post-burn respectively and correlated statistically with relative insulin resistance evidenced by elevated serum glucose and insulin levels after a glucose challenge [Dasu et al. DOI:10.01.TA.0000053195.32115.9C].