Basic Information

Symbol
REV1
RNA class
mRNA
Alias
REV1 DNA Directed Polymerase REV1L Rev1-Like Terminal Deoxycytidyl Transferase Alpha Integrin-Binding Protein 80 REV1, Polymerase (DNA Directed) DNA Repair Protein REV1 AIBP80 REV1 Homolog (S. Cerevisiae) REV1 (Yeast Homolog)- Like REV1-Like (Yeast) REV1 Homolog REV1- Like EC 2.7.7.-
Location (GRCh38)
2:99400475-99490260
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016316.4
Sequence length
4731.0 nt
GC content
0.4295

Transcripts

ID Sequence Length GC content
NM_001037872.3 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4728 nt 0.4294
NM_001321454.2 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4839 nt 0.4317
NM_001321455.2 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4885 nt 0.4278
NM_001321458.2 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4855 nt 0.4317
NM_001321459.2 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4931 nt 0.4336
NM_001321460.2 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4928 nt 0.4334
NM_016316.4 NCBI
GAGCCACCGCGGAGCGCGCGCGGGGUUGGUUGCCGCGAGCGUGGGGGAG… 4731 nt 0.4295
Summary

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

Forensic Context

A study in humans integrating summary data-based Mendelian randomization with single-cell RNA sequencing identified the REV1 as one of 17 genes whose expression levels are pleiotropically associated with sepsis [Yang et al. DOI:10.1111/jcmm.18559].