Basic Information

Symbol
REV3L
RNA class
mRNA
Alias
REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit POLZ REV3 REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit DNA Polymerase Zeta Catalytic Subunit EC 2.7.7.7 REV3 (Yeast Homolog)-Like, Catalytic Subunit Of DNA Polymerase Zeta REV3-Like, Catalytic Subunit Of DNA Polymerase Zeta (Yeast) Rev-3, Yeast, Homolog-Like (Polymerase, DNA, Zeta) Protein Reversionless 3-Like Polymerase, DNA, Zeta REV3-Like EC 2.7.7 HREV3
Location (GRCh38)
6:111299028-111483715
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001372078.1
Sequence length
10706.0 nt
GC content
0.3988

Transcripts

ID Sequence Length GC content
NM_001286431.2 NCBI
GAGAUCUGCGCCUCGCCUCCCUCCUCACGCGGGCGGAUUUUCUUACCUU… 11065 nt 0.4001
NM_001286432.2 NCBI
GAGAUCUGCGCCUCGCCUCCCUCCUCACGCGGGCGGAUUUUCUUACCUU… 10958 nt 0.3998
NM_001372078.1 NCBI
GUGACAUCAUCAUCAUGGCAACAAGAGCUGCAGCCUGGGACCGAGGAGC… 10706 nt 0.3988
NM_002912.5 NCBI
GAGAUCUGCGCCUCGCCUCCCUCCUCACGCGGGCGGAUUUUCUUACCUU… 10830 nt 0.4015
Summary

The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]

Forensic Context

A study in mice demonstrated that the REV3L transcript, encoding the DNA polymerase zeta catalytic subunit, increased in abundance at 1 hour postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].