Basic Information

Symbol
RFC4
RNA class
mRNA
Alias
Replication Factor C Subunit 4 RFC37 Activator 1 37 KDa Subunit A1 37 KDa Subunit A1 Replication Factor C (Activator 1) 4, 37kDa Replication Factor C 37 KDa Subunit Activator 1 Subunit 4 RF-C 37 KDa Subunit RFC 37 KDa Subunit Replication Factor C (Activator 1) 4 (37kD) MRMNS
Location (GRCh38)
3:186789880-186807058
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002916.5
Sequence length
1365.0 nt
GC content
0.4403

Transcripts

ID Sequence Length GC content
NM_002916.5 NCBI
GCUUUUCGCCCGCCGUUCCGUGGCGGGAACUGAGGCGACUGUGGGGACA… 1365 nt 0.4403
NM_181573.3 NCBI
GCUUUUCGCCCGCCGUUCCGUGGCGGGAACUGAGGCGACUGUGGGGACA… 1230 nt 0.4276
Summary

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human neonates with hypoxic-ischemic encephalopathy (HIE) identified the RFC4 as one of 11 significant genes commonly associated with adverse outcome (death or disability) across cohorts from high-income countries and South Asia, though its expression was downregulated in the former and upregulated in the latter cohort in cases with adverse outcomes [Montaldo et al. DOI:10.1001/jamanetworkopen.2023.54433].