Basic Information

Symbol
RFX4
RNA class
mRNA
Alias
Regulatory Factor X4 Regulatory Factor X, 4 (Influences HLA Class II Expression) Testis Development Protein NYD-SP10 Transcription Factor RFX4 Winged-Helix Transcription Factor RFX4 Regulatory Factor X 4 NYD-SP10
Location (GRCh38)
12:106582691-106762803
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_213594.3
Sequence length
3859.0 nt
GC content
0.4646

Transcripts

ID Sequence Length GC content
NM_001206691.2 NCBI
AACCCACUGACCUGAGCCACCCCCUGGAGAGGCCACAGCUGCUGGCUUC… 3698 nt 0.4673
NM_032491.6 NCBI
AGUUGAGAAGUAGUAGAAGACACGGAAGGCACAGAAGGCAGACUUCGCU… 3345 nt 0.4568
NM_213594.3 NCBI
GCAAACAUUUUGACGGGUUUGGCUUUGCCCGGCUGGAUUACUGAGUGUC… 3859 nt 0.4646
Summary

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Forensic Context

A review of RNA-Seq studies in post-mortem human brains notes that RFX4 exhibits altered expression in the dorsolateral prefrontal cortex of subjects with bipolar disorder, where it is implicated in the dysregulation of circadian rhythms [Wu et al. DOI:10.1111/Pcn.12550].