Basic Information

Symbol
RGN
RNA class
mRNA
Alias
Regucalcin SMP30 RC Gluconolactonase Senescence Marker Protein 30 GNL Regucalcin (Senescence Marker Protein-30) Epididymis Secretory Protein Li 41 Senescence Marker Protein-30 EC 3.1.1.17 HEL-S-41 SMP-30
Location (GRCh38)
X:47078190-47094419
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_152869.4
Sequence length
2168.0 nt
GC content
0.4954

Transcripts

ID Sequence Length GC content
NM_001282848.2 NCBI
AGACCCGCUCAUCCCGAUCUCCCAGAAGGCGACUGACAGCUGACUGCCA… 2119 nt 0.4960
NM_001282849.2 NCBI
AGACCCGCUCAUCCCGAUCUCCCAGAAGGCGACUGACAGCUGACUGCCA… 1952 nt 0.4944
NM_004683.6 NCBI
AGACCCGCUCAUCCCGAUCUCCCAGAAGGCGACUGACAGCUGACUGCCA… 1548 nt 0.4955
NM_152869.4 NCBI
AGACCCGCUCAUCCCGAUCUCCCAGAAGGCGACUGACAGCUGACUGCCA… 2168 nt 0.4954
Summary

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Forensic Context

A study in the forensically important blow fly *Lucilia sericata* demonstrated that the RGN is a molecular marker for intra-puparial age estimation, with its expression first declining until day 4 of development before increasing to surpass prepupal levels [Pereira et al. DOI:10.1007/s00414-025-03537-8].