Basic Information

Symbol
RGS1
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 1 1R20 BL34 Regulator Of G-Protein Signaling 1 IR20 IER1 Regulator Of G-Protein Signalling 1 B-Cell Activation Protein BL34 Early Response Protein 1R20 Immediate-Early Response 1, B-Cell Specific Epididymis Secretory Protein Li 87 HEL-S-87
Location (GRCh38)
1:192575763-192580024
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Forensic psychiatry evaluation Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002922.4
Sequence length
1352.0 nt
GC content
0.3757

Transcripts

ID Sequence Length GC content
NM_002922.4 NCBI
GCAUAUUUGCUAAGAGCACCAUGCGCGCAGCAGCCAUCUCCACUCCAAA… 1352 nt 0.3757
Summary

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the RGS1 as a key hub gene via LASSO regression and PPI network analysis, demonstrating its significant upregulation in both myocardial infarction and Alzheimer's disease patient samples compared to controls (p < 0.0001) [Xue et al. DOI:10.3233/JAD-230559]. A study in mice demonstrated that the RGS1 mRNA expression was additively up-regulated in heart tissue by both methamphetamine administration and physical restraint, suggesting its involvement in hypertension through the renin-angiotensin-aldosterone system [Shinone et al. DOI:10.1016/J.Legalmed.2010.01.001]. In a separate study in mice, chronic cocaine exposure and withdrawal in the nucleus accumbens led to a sustained decrease in the RGS1 mRNA expression [Eipper-Mains et al. DOI:10.1111/J.1601-183X.2012.00873.X].