Basic Information

Symbol
RGS20
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 20 RGSZ1 ZGAP1 Regulator Of G-Protein Signaling 20 Regulator Of Gz-Selective Protein Signaling 1 Gz-Selective GTPase-Activating Protein Regulator Of G-Protein Signalling 20 Regulator Of G-Protein Signaling Z1 G(Z)GAP Gz-GAP
Location (GRCh38)
8:53851795-53959303
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003702.5
Sequence length
1715.0 nt
GC content
0.4531

Transcripts

ID Sequence Length GC content
NM_001286673.2 NCBI
AGAGCCAGCCCAGCAUUAACCAAACAAAGAGAAGCAGAGUGGAUCCUGU… 1772 nt 0.4261
NM_001286674.2 NCBI
AGAGCCAGCCCAGCAUUAACCAAACAAAGAGAAGCAGAGUGGAUCCUGU… 1539 nt 0.3977
NM_001286675.2 NCBI
AGAGCCAGCCCAGCAUUAACCAAACAAAGAGAAGCAGAGUGGAUCCUGU… 1623 nt 0.4023
NM_003702.5 NCBI
AGAGCAAGGGGAGGAAGAGGCCGGGAGAAGAGGGCUAGAGCAAAGACCG… 1715 nt 0.4531
NM_170587.4 NCBI
AGAGCCAGCCCAGCAUUAACCAAACAAAGAGAAGCAGAGUGGAUCCUGU… 2117 nt 0.4757
Summary

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Forensic Context

A review of transcriptomic studies in human populations highlighted that the RGS20 mRNA transcript was reported as differentially expressed between individuals of Asian and European descent in lymphoblastoid cell lines [Daca-Roszak et al. DOI:10.1007/s13353-019-00510-1].