Basic Information

Symbol
RGS5
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 5 Regulator Of G-Protein Signaling 5 Regulator Of G-Protein Signalling 5 MSTP032 MSTP092 MSTP106 MSTP129 MST092 MST106 MST129
Location (GRCh38)
1:163111121-163321791
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003617.4
Sequence length
5670.0 nt
GC content
0.3605

Transcripts

ID Sequence Length GC content
NM_001414479.1 NCBI
AUCUCUGCGUGACUUCCGCCAGCGUUUAGAGCGUUUUCGGGGUCCGAGU… 5866 nt 0.3643
NM_003617.4 NCBI
AGACAGUUUUGAAGUUUUCAAAGACUGGCUCUGCUGUUAAGAAGUUGUA… 5670 nt 0.3605
Showing 11 to 12 of 12 entries
Summary

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

Forensic Context

A study in human corpus cavernosum tissue identified RGS5 as a gene marker highly expressed in the vascular smooth muscle cell (VSMC) cluster [Zhao et al. DOI:10.1038/s41467-022-31950-9]. A subsequent cross-species analysis in human and rat tissues confirmed RGS5 as a marker for vascular SMCs in humans, while in rats, VSMCs could also be distinguished by high expression of Rgs5 [Yin et al. DOI:10.1016/j.celrep.2024.114760].