Basic Information

Symbol
RGS7
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 7 Regulator Of G-Protein Signaling 7 Regulator Of G-Protein Signalling 7 Regulator Of G-Protein Signaling RGS7
Location (GRCh38)
1:240767636-241357374
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001364886.1
Sequence length
2551.0 nt
GC content
0.4618

Transcripts

ID Sequence Length GC content
NM_001282773.2 NCBI
GUCGCGCGCACGGGCCGGGCGUCUCGACUCCCGCGCGCGCUCGGCUGGU… 2371 nt 0.4656
NM_001282775.2 NCBI
GUCGCGCGCACGGGCCGGGCGUCUCGACUCCCGCGCGCGCUCGGCUGGU… 2530 nt 0.4660
NM_001282778.2 NCBI
GUCGCGCGCACGGGCCGGGCGUCUCGACUCCCGCGCGCGCUCGGCUGGU… 2449 nt 0.4667
NM_001350113.2 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 2601 nt 0.4598
NM_001350114.2 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 2569 nt 0.4609
NM_001350115.2 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 2520 nt 0.4603
NM_001350116.1 NCBI
GGCACACUGAUAAUUCUUGUAUCUUGAGAGUGGACCAAGUUUUGGGUGA… 2189 nt 0.4180
NM_001364886.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 2551 nt 0.4618
NM_001374806.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3218 nt 0.4369
NM_001374807.1 NCBI
GCCUGCACCCAGCCCGCCCGGGAGGGGAGACGCCGCGGGGCCGUGACCU… 2890 nt 0.4100
Showing 1 to 10 of 20 entries
Summary

Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that brief ethanol exposure significantly activated the expression of numerous alcohol-responsive genes in primary cortical astrocytes, including the RGS7 which was upregulated alongside other inflammatory-immune response markers [Pignataro et al. DOI:10.1002/Brb3.125]. In humans, transcriptional network analysis of postmortem prefrontal cortex identified coexpression modules for lifetime alcohol consumption that were significantly enriched for genetic variants from alcohol dependence GWAS and for genes from a meta-analysis of alcohol-drinking behavior in mice [Farris et al. DOI:10.1038/Mp.2014.159].