Basic Information

Symbol
RGS7
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 7 Regulator Of G-Protein Signaling 7 Regulator Of G-Protein Signalling 7 Regulator Of G-Protein Signaling RGS7
Location (GRCh38)
1:240767636-241357374
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001364886.1
Sequence length
2551.0 nt
GC content
0.4618

Transcripts

ID Sequence Length GC content
NM_001374808.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3415 nt 0.4375
NM_001374809.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3198 nt 0.4353
NM_001374810.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3333 nt 0.4344
NM_001374811.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3029 nt 0.4331
NM_001374812.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3113 nt 0.4353
NM_001374813.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 2964 nt 0.4285
NM_001374814.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3164 nt 0.4324
NM_001374815.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3158 nt 0.4341
NM_001374816.1 NCBI
GACUCCCGCGCGCGCUCGGCUGGUCCCAGUCCCCGGGAGAAGAAGCGGA… 3077 nt 0.4339
NM_002924.6 NCBI
GUCGCGCGCACGGGCCGGGCGUCUCGACUCCCGCGCGCGCUCGGCUGGU… 2503 nt 0.4646
Showing 11 to 20 of 20 entries
Summary

Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that brief ethanol exposure significantly activated the expression of numerous alcohol-responsive genes in primary cortical astrocytes, including the RGS7 which was upregulated alongside other inflammatory-immune response markers [Pignataro et al. DOI:10.1002/Brb3.125]. In humans, transcriptional network analysis of postmortem prefrontal cortex identified coexpression modules for lifetime alcohol consumption that were significantly enriched for genetic variants from alcohol dependence GWAS and for genes from a meta-analysis of alcohol-drinking behavior in mice [Farris et al. DOI:10.1038/Mp.2014.159].