Basic Information

Symbol
RGS9
RNA class
mRNA
Alias
Regulator Of G Protein Signaling 9 Regulator Of G-Protein Signaling 9 PERRS RGS9L Regulator Of G-Protein Signalling 9 MGC111763 MGC26458 Regulator Of G Protein Signalling 9L Regulator Of G Protein Signalling 9 Regulator Of G-Protein Signaling 9L PERRS1
Location (GRCh38)
17:65100812-65227703
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003835.4
Sequence length
2492.0 nt
GC content
0.5546

Transcripts

ID Sequence Length GC content
NM_001081955.3 NCBI
AGUCAGCGGCGCCUAGUGAGAGUCAGGGGGGCCCGGCCCGCGCCCUCCC… 2483 nt 0.5550
NM_001165933.2 NCBI
AGUCAGCGGCGCCUAGUGAGAGUCAGGGGGGCCCGGCCCGCGCCCUCCC… 4226 nt 0.4867
NM_003835.4 NCBI
AGUCAGCGGCGCCUAGUGAGAGUCAGGGGGGCCCGGCCCGCGCCCUCCC… 2492 nt 0.5546
Summary

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Forensic Context

A study in mice demonstrated that the RGS9 was found in a nucleus accumbens network module that was protected from differential wiring changes associated with selective breeding for high versus low methamphetamine intake, and this module was enriched for G protein-coupled receptor signaling pathway annotations [Hitzemann et al. DOI:10.3390/brainsci9070155].