Basic Information

Symbol
RHOA
RNA class
mRNA
Alias
Ras Homolog Family Member A RHOH12 Rho12 ARH12 ARHA Transforming Protein RhoA Epididymis Secretory Sperm Binding Protein Ras Homolog Gene Family, Member A Aplysia Ras-Related Homolog 12 Small GTP Binding Protein RhoA Rho CDNA Clone 12 Oncogene RHO H12 EC 3.6.5.2 EDFAOB RHO12 H12
Location (GRCh38)
3:49359136-49412998
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001664.4
Sequence length
1805.0 nt
GC content
0.4526

Transcripts

ID Sequence Length GC content
NM_001313941.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1900 nt 0.4553
NM_001313943.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1944 nt 0.4640
NM_001313944.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1745 nt 0.4493
NM_001313945.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1682 nt 0.4471
NM_001313946.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1553 nt 0.4456
NM_001313947.2 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1684 nt 0.4495
NM_001664.4 NCBI
GCUCUCUCGCGCUACCCUCCCGCCGCCCGCGGUCCUCCGUCGGUUCUCU… 1805 nt 0.4526
Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] CIViC Summary for RHOA Gene

Forensic Context

A study in rats using an organotypic hippocampal slice model of traumatic brain injury demonstrated that the RHOA was implicated in a specific neurodegenerative pathway following a severe (50% Lagrangian stretch) mechanical insult, where it was positively regulated by the upregulated myelin inhibitor Nogo-A (Rtn4) and associated with increased susceptibility to apoptosis [Di Pietro et al. DOI:10.1089/neu.2009.1095].