Basic Information

Symbol
RHOB
RNA class
mRNA
Alias
Ras Homolog Family Member B MST081 RHOH6 ARH6 ARHB Rho-Related GTP-Binding Protein RhoB Ras Homolog Gene Family, Member B Rho CDNA Clone 6 Oncogene RHO H6 H6 Aplysia RAS-Related Homolog 6 MSTP081
Location (GRCh38)
2:20447074-20449440
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004040.4
Sequence length
2367.0 nt
GC content
0.5746

Transcripts

ID Sequence Length GC content
NM_004040.4 NCBI
AUCUGCCACCGCAGUCUGGUUGGAGCUGUUGUCUUGUAUGCUCAGCGAG… 2367 nt 0.5746
Summary

Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans analyzing blood samples from pediatric and adult burn patients using a factorial time-course microarray method (TANOVA) identified that the RHOB exhibited a main effect related only to age and not to burn injury, classifying it into a group of genes involved in processes like nitric oxide and reactive oxygen species production in macrophages associated with aging [Zhou et al. DOI:10.1073/pnas.1002757107].