Basic Information

Symbol
RIGI
RNA class
mRNA
Alias
RNA Sensor RIG-I RIG-I Antiviral Innate Immune Response Receptor RIG-I RIG-1 DDX58 RIG1 DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Retinoic Acid-Inducible Gene 1 Protein Retinoic Acid-Inducible Gene I Protein ATP-Dependent RNA Helicase DDX58 DExD/H-Box Helicase 58 DEAD Box Protein 58 RNA Helicase RIG-I DKFZp434J1111 FLJ13599 RLR-1 DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide Probable ATP-Dependent RNA Helicase DDX58 Retinoic Acid Inducible Gene I RIG-I-Like Receptor 1 EC 3.6.4.13 SGMRT2
Location (GRCh38)
9:32455302-32526348
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014314.4
Sequence length
4628.0 nt
GC content
0.3991

Transcripts

ID Sequence Length GC content
NM_001385907.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4622 nt 0.3992
NM_001385909.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4457 nt 0.3976
NM_001385910.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4641 nt 0.3991
NM_001385912.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4480 nt 0.3982
NM_001385913.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4613 nt 0.3993
NM_001385914.1 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4638 nt 0.3991
NM_014314.4 NCBI
GAACGUAGCUAGCUGCAAGCAGAGGCCGGCAUGACCACCGAGCAGCGAC… 4628 nt 0.3991
Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

Forensic Context

A study in rats demonstrated that the RIGI (DEXD/H-box helicase 58) was core-enriched in downregulated immune-associated datasets in fetal cardiac fibroblasts compared with neonatal cardiac fibroblasts, identifying it as an innate immune response receptor whose expression is developmentally regulated [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021]. A study in diverse RNA constructs demonstrated that computational models developed via a dual-crowdsourcing approach could predict RNA degradation patterns with high accuracy, with 41% of nucleotide-level predictions from the winning model within experimental error [Wayment-Steele et al. DOI:10.1038/s42256-022-00571-8].