Basic Information

Symbol
RIMS1
RNA class
mRNA
Alias
Regulating Synaptic Membrane Exocytosis 1 RIM1 KIAA0340 RAB3IP2 RIM Regulating Synaptic Membrane Exocytosis Protein 1 Rab-3-Interacting Protein 2 CORD7 Rab-3-Interacting Molecule 1 Rab3-Interacting Molecule 1 RAB3 Interacting Protein 2 RAB3-Interacting Protein 2 Rab3-Interacting Molecule RIM 1
Location (GRCh38)
6:71886550-72403150
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014989.7
Sequence length
7984.0 nt
GC content
0.4792

Transcripts

ID Sequence Length GC content
NM_001168407.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5700 nt 0.4172
NM_001168408.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5115 nt 0.4104
NM_001168409.2 NCBI
AGUUGUCAUUGAGCUGAGUAAGAUUCCUCAGUUAGGGAAACUGCAGAGG… 4975 nt 0.4092
NM_001168410.2 NCBI
GUUCACUGCAGAGAUCUGUUUUGAUGACAGCAGCACUUAUGGCCUUGUU… 5160 nt 0.4074
NM_001168411.2 NCBI
AGACAGAUAUUCCAGCCAGCCACCGCACAAGUUAUUUAAACCAGGUCAA… 3265 nt 0.3905
NM_001350414.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5661 nt 0.4158
NM_001350415.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5757 nt 0.4191
NM_001350416.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5706 nt 0.4162
NM_001350417.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5187 nt 0.4110
NM_001350418.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5679 nt 0.4159
Showing 1 to 10 of 65 entries
Summary

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that the RIMS1 is enriched in pseudo-time expression clusters during neurotransmitter phenotype switching in the ventral tegmental area during nicotine addiction progression [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].