Basic Information

Symbol
RIMS1
RNA class
mRNA
Alias
Regulating Synaptic Membrane Exocytosis 1 RIM1 KIAA0340 RAB3IP2 RIM Regulating Synaptic Membrane Exocytosis Protein 1 Rab-3-Interacting Protein 2 CORD7 Rab-3-Interacting Molecule 1 Rab3-Interacting Molecule 1 RAB3 Interacting Protein 2 RAB3-Interacting Protein 2 Rab3-Interacting Molecule RIM 1
Location (GRCh38)
6:71886550-72403150
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014989.7
Sequence length
7984.0 nt
GC content
0.4792

Transcripts

ID Sequence Length GC content
NM_001350419.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 4959 nt 0.4081
NM_001350420.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5814 nt 0.4205
NM_001350421.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5716 nt 0.4178
NM_001350422.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5184 nt 0.4111
NM_001350423.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5448 nt 0.4146
NM_001350424.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5203 nt 0.4117
NM_001350425.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5658 nt 0.4159
NM_001350426.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5034 nt 0.4088
NM_001350427.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5112 nt 0.4104
NM_001350428.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5275 nt 0.4123
Showing 11 to 20 of 65 entries
Summary

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that the RIMS1 is enriched in pseudo-time expression clusters during neurotransmitter phenotype switching in the ventral tegmental area during nicotine addiction progression [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].