Basic Information

Symbol
RIMS1
RNA class
mRNA
Alias
Regulating Synaptic Membrane Exocytosis 1 RIM1 KIAA0340 RAB3IP2 RIM Regulating Synaptic Membrane Exocytosis Protein 1 Rab-3-Interacting Protein 2 CORD7 Rab-3-Interacting Molecule 1 Rab3-Interacting Molecule 1 RAB3 Interacting Protein 2 RAB3-Interacting Protein 2 Rab3-Interacting Molecule RIM 1
Location (GRCh38)
6:71886550-72403150
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014989.7
Sequence length
7984.0 nt
GC content
0.4792

Transcripts

ID Sequence Length GC content
NM_001350449.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5094 nt 0.4099
NM_001350450.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5200 nt 0.4117
NM_001350452.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 2274 nt 0.4314
NM_001350454.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5610 nt 0.4162
NM_001350455.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 4962 nt 0.4081
NM_001350456.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5883 nt 0.4210
NM_001350457.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5640 nt 0.4163
NM_001350458.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5709 nt 0.4160
NM_001350459.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5719 nt 0.4177
NM_001350460.2 NCBI
GCACAGUGCCUGCAGUGACCUGAGUCAGUCAUGCAAGGAGACUUUCUUG… 5580 nt 0.4145
Showing 41 to 50 of 65 entries
Summary

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that the RIMS1 is enriched in pseudo-time expression clusters during neurotransmitter phenotype switching in the ventral tegmental area during nicotine addiction progression [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].