Basic Information

Symbol
RIMS1
RNA class
mRNA
Alias
Regulating Synaptic Membrane Exocytosis 1 RIM1 KIAA0340 RAB3IP2 RIM Regulating Synaptic Membrane Exocytosis Protein 1 Rab-3-Interacting Protein 2 CORD7 Rab-3-Interacting Molecule 1 Rab3-Interacting Molecule 1 RAB3 Interacting Protein 2 RAB3-Interacting Protein 2 Rab3-Interacting Molecule RIM 1
Location (GRCh38)
6:71886550-72403150
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014989.7
Sequence length
7984.0 nt
GC content
0.4792

Transcripts

ID Sequence Length GC content
NM_001350471.2 NCBI
GUUCACUGCAGAGAUCUGUUUUGAUGACAGCAGCACUUAUGGCCUUGUU… 5671 nt 0.4140
NM_001350472.2 NCBI
GUUCACUGCAGAGAUCUGUUUUGAUGACAGCAGCACUUAUGGCCUUGUU… 5085 nt 0.4067
NM_001350473.2 NCBI
GUUCACUGCAGAGAUCUGUUUUGAUGACAGCAGCACUUAUGGCCUUGUU… 5088 nt 0.4066
NM_001350474.2 NCBI
GUUCACUGCAGAGAUCUGUUUUGAUGACAGCAGCACUUAUGGCCUUGUU… 5451 nt 0.4113
NM_014989.7 NCBI
AAAUUGGAGGCAGCAGAGCCUGGGAGCAGCCUCCACGGCGGCAGCGGCC… 7984 nt 0.4792
Showing 61 to 65 of 65 entries
Summary

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that the RIMS1 is enriched in pseudo-time expression clusters during neurotransmitter phenotype switching in the ventral tegmental area during nicotine addiction progression [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].