Basic Information

Symbol
RIPK1
RNA class
mRNA
Alias
Receptor Interacting Serine/Threonine Kinase 1 RIP-1 RIP1 RIP Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1 Receptor-Interacting Serine/Threonine-Protein Kinase 1 Receptor-Interacting Protein Kinase 1 Receptor-Interacting Protein 1 Cell Death Protein RIP Serine/Threonine-Protein Kinase RIP EC 2.7.11.1 AIEFL IMD57
Location (GRCh38)
6:3063824-3115187
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001354930.2
Sequence length
4092.0 nt
GC content
0.4900

Transcripts

ID Sequence Length GC content
NM_001317061.3 NCBI
GGGAGUCCGCGGCGAGCGCAGCAGCAGGGCCCGGUCCUGCGCCUCGGGA… 4295 nt 0.4875
NM_001354930.2 NCBI
AGUCCACGCCCUCCAGCCGGGCGCGCUCGACGCGGACGGCGGGCCAGCU… 4092 nt 0.4900
NM_001354931.2 NCBI
GGGAGUCCGCGGCGAGCGCAGCAGCAGGGCCCGGUCCUGCGCCUCGGGA… 3879 nt 0.4870
NM_001354932.2 NCBI
GGGAGUCCGCGGCGAGCGCAGCAGCAGGGCCCGGUCCUGCGCCUCGGGA… 4131 nt 0.4837
NM_001354933.2 NCBI
AGUCCACGCCCUCCAGCCGGGCGCGCUCGACGCGGACGGCGGGCCAGCU… 4206 nt 0.4903
NM_001354934.2 NCBI
GCAAGAGAGCUCCGGGACUCAGACCCCGGGCGCGAGGUCCCACGAGCGG… 4517 nt 0.5079
NM_003804.6 NCBI
GGGAGUCCGCGGCGAGCGCAGCAGCAGGGCCCGGUCCUGCGCCUCGGGA… 4017 nt 0.4832
Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

Forensic Context

A study in mice demonstrated that hypothermia exposure significantly increased the protein levels of the RIPK1 in the cerebral cortex, where it functions as a necroptosis mediator [Wang et al. DOI:10.1186/s11658-025-00772-0].