Basic Information

Symbol
RIPK2
RNA class
mRNA
Alias
Receptor Interacting Serine/Threonine Kinase 2 CARDIAK RICK RIP2 CARD3 Receptor-Interacting Serine/Threonine-Protein Kinase 2 CARD-Containing IL-1 Beta ICE-Kinase Receptor-Interacting Protein 2 Tyrosine-Protein Kinase RIPK2 EC 2.7.11.1 RIP-2 Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis Regulatory Protein (CLARP) Kinase CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated Kinase CARD-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase Receptor-Interacting Serine-Threonine Kinase 2 RIP-Like-Interacting CLARP Kinase Growth-Inhibiting Gene 30 CARD-Carrying Kinase EC 2.7.10.2 EC 2.7.11 GIG30 CCK
Location (GRCh38)
8:89757783-89791064
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003821.6
Sequence length
2516.0 nt
GC content
0.4157

Transcripts

ID Sequence Length GC content
NM_001375360.1 NCBI
CUUUCGCGGCGCUACGGCGUUGGCACCAGUCUCUAGAAAAGAAGUCAGC… 2362 nt 0.4213
NM_003821.6 NCBI
CUUUCGCGGCGCUACGGCGUUGGCACCAGUCUCUAGAAAAGAAGUCAGC… 2516 nt 0.4157
Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human prostate tissues demonstrated that the RIPK2 was significantly upregulated at longer postmortem intervals (96 h and 120 h) compared to a 24 h control, as validated by PCR Array and statistical analysis [Tolbert et al. DOI:10.1016/j.gene.2018.06.090].