Basic Information

Symbol
RIPK3
RNA class
mRNA
Alias
Receptor Interacting Serine/Threonine Kinase 3 RIP3 Receptor-Interacting Serine/Threonine-Protein Kinase 3 RIP-Like Protein Kinase 3 RIP-3 Receptor-Interacting Serine-Threonine Kinase 3 Receptor Interacting Protein 3 Receptor-Interacting Protein 3 EC 2.7.11.1
Location (GRCh38)
14:24336025-24340022
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006871.4
Sequence length
1872.0 nt
GC content
0.5582

Transcripts

ID Sequence Length GC content
NM_006871.4 NCBI
GGAAAAAGGGUAACAACCCGGAAAGUAGACUCACCGUCUUGGUCUAGAG… 1872 nt 0.5582
Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that hypothermia exposure significantly increased the protein levels of the RIPK3 in the cerebral cortex, where it functions as a key mediator of necroptosis [Wang et al. DOI:10.1186/s11658-025-00772-0].