Basic Information

Symbol
RNASE1
RNA class
mRNA
Alias
Ribonuclease A Family Member 1, Pancreatic RAC1 RNS1 Ribonuclease, RNase A Family, 1 (Pancreatic) Ribonuclease Pancreatic Ribonuclease 1 RNase UpI-1 HP-RNase RNase 1 RNase A RIB-1 RIB1 Ribonuclease A C1 Ribonuclease A EC 4.6.1.18 EC 3.1.27.5
Location (GRCh38)
14:20801228-20802884
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002933.5
Sequence length
914.0 nt
GC content
0.5306

Transcripts

ID Sequence Length GC content
NM_002933.5 NCBI
GCAGAAACUGGCCUUCCAUCUCUCUCAGACACCAAGCUGCAGAUCCAGG… 914 nt 0.5306
NM_198232.3 NCBI
AGUAUUCAAAGAUAGGAACUGACAGGAUUUUAGGUCACUUUGUAGGUCA… 982 nt 0.5224
NM_198234.3 NCBI
GCAGAAACUGGCCUUCCAUCUCUCUCAGACACCAAGCUGCAGAUCCAGG… 985 nt 0.5310
NM_198235.3 NCBI
GCAGAAACUGGCCUUCCAUCUCUCUCAGACACCAAGCUGCAGAUCCAGG… 997 nt 0.5296
Summary

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the RNASE1 was associated with the inhibited autophagy pathway in the brain and lungs in sepsis [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938]. A study in mice demonstrated that the RNASE1 was upregulated in common in white blood cells at day 1 post-injury following both burn and trauma-hemorrhage, where it was identified as a gene expression marker associated with the cell death pathway [Lederer et al. DOI:10.1152/physiolgenomics.00086.2007].