Basic Information

Symbol
RNASE2
RNA class
mRNA
Alias
Ribonuclease A Family Member 2 EDN Eosinophil-Derived Neurotoxin RAF3 RNS2 Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) Non-Secretory Ribonuclease Ribonuclease US Ribonuclease 2 RNase UpI-2 RNase 2 Ribonuclease A F3 EC 4.6.1.18 EC 3.1.27.5
Location (GRCh38)
14:20955487-20956436
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002934.3
Sequence length
720.0 nt
GC content
0.4542

Transcripts

ID Sequence Length GC content
NM_002934.3 NCBI
AGAACAACCAGCUGGAUCAGUUCUCACAGGAGCUACAGCGCGGAGACUG… 720 nt 0.4542
Summary

The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

Forensic Context

A study in humans identified the RNASE2 as a significantly upregulated diagnostic gene marker in blood samples from patients with infective endocarditis and sepsis, demonstrating excellent diagnostic performance with an AUC > 0.781 [Chen et al. DOI:10.3389/fimmu.2023.1298041]. Separate research in humans also identified the RNASE2 as a significantly upregulated immune-related gene and potential biomarker in blood samples from burn injury patients, with its expression pattern validated by an external cohort and qRT-PCR [Niu et al. DOI:10.1093/jbcr/irad050]. A study in mice demonstrated that the RNASE2 gene (RNASE2) was downregulated in common in spleen leukocytes across all three injury models of trauma/hemorrhage, burn, and LPS infusion at a 2-hour post-injury time point [Brownstein et al. DOI:10.1152/physiolgenomics.00213.2005].