Basic Information

Symbol
RNASE3
RNA class
mRNA
Alias
Ribonuclease A Family Member 3 ECP Eosinophil Cationic Protein RAF1 RNS3 Ribonuclease, RNase A Family, 3 Ribonuclease 3 RNase 3 Cytotoxic Ribonuclease EC 3.1.27.- EC 3.1.27.5 EC 3.1.27
Location (GRCh38)
14:20891385-20892348
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002935.3
Sequence length
734.0 nt
GC content
0.4796

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-203.30 kcal/mol
Thermodynamic ensemble
Free energy: -216.35 kcal/mol
Frequency: 0.0000
Diversity: 159.23
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((...((((.........)))).))))...((((((((((....))))((((((..(((...((((.((.....((((...(((((....(((((((((.....((((.((((((....(((((((((......))))))))))).)))).))))....((((((.((((((((.(((......))).))))..))))....)))))).((((....))))(((((.(((.............((((((((((...........(((((((......((((((.((.((((...)))).)).).)))))......)))))))...(((.........))).........))).)))))))((((((((....((...)))))))))).(((((((((.........)))).)))))............))).))))))))))))))...)))))((((..((..((((.((...((((.....(((..(((((((((.((....)).))))))))).(((((.....))))).................((((....))))..)))....)))).)).))))..))..))))....))))....))..))))...)))..)).))))((((((.....((((.......))))....))))))(((((((((....)))))))))....))))))....(((((.........)))))......
Thermodynamic Ensemble Prediction
...,,...((((...((((.........)))).}}})...((((((((((....)))|((((((,,(((...{(((,{,.....,,,,...(((((....(((((((((.....((((.((((,{....(((((((((......)))))))))}}.}))),))))....,((((({,,((((((.((({{{{{{|,|{,,,.}}))),....|||,||.((((....}))),||.}}}...............}})}))|{{,,...,,,....(((((((..,,..((((((.,{.((({...)))).,}.)})))))..,,..))))))).}}}}))))}).,.,.,|,.............||{,{.((((((((....{,..,,.)))))))).{{|||||{{.........})||,|}}}}............})}}},,..)))))))))...)))))((((..((..((((.((...((((.....(((..(((((((((.({....)).))))))))).(((((.....))))).............{{,.(((,...,)})),.)))....)))).)).))))..))..))))......,}....}},.)))}...})}..)).))))|(((((..{..((((.......))))....)))))}(((((((((....)))))))))...,})))))....{((((.........)))))......

Transcripts

ID Sequence Length GC content
NM_002935.3 NCBI
AGCUGCCCCUGAACCCCAGAACAACCAGCUGGAUCAGUUCUCACAGGAG… 734 nt 0.4796
Summary

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

Forensic Context

A study in human sepsis patients demonstrated that the RNASE3 (RNASE3) was significantly upregulated in peripheral blood and was adversely associated with 28-day survival [Li et al. DOI:10.1515/biol-2022-0999]. A study in human burn patients identified the RNASE3 as one of 19 center genes commonly differentially expressed in blood across early-stage, middle-stage, and control group comparisons, indicating its association with burn injury progression [Wu et al. DOI:10.007/s10753-018-0829-0].