Basic Information

Symbol
RNF125
RNA class
mRNA
Alias
Ring Finger Protein 125 Ring Finger Protein 125, E3 Ubiquitin Protein Ligase E3 Ubiquitin-Protein Ligase RNF125 FLJ20456 TRAC-1 T-Cell Ring Protein Identified In Activation Screen T-Cell RING Activation Protein 1 RING Finger Protein 125 EC 2.3.2.27 TNORS TRAC1
Location (GRCh38)
18:32018174-32088144
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017831.4
Sequence length
5573.0 nt
GC content
0.3996

Transcripts

ID Sequence Length GC content
NM_017831.4 NCBI
ACUGAGUGCUUCGCAGCUGUCUGGGCGAGAGGCACAGCGAUGGGCUCCG… 5573 nt 0.3996
Summary

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that the RNF125 was selected from a microarray analysis of heart tissue following methamphetamine administration and restraint, but quantitative RT-PCR validation did not show a statistically significant change in its mRNA expression [Shinone et al. DOI:10.1016/J.Legalmed.2010.01.001].