Basic Information

Symbol
RNF139
RNA class
mRNA
Alias
Ring Finger Protein 139 TRC8 HRCA1 RCA1 Translocation In Renal Carcinoma On Chromosome 8 Protein Translocation In Renal Carcinoma, Chromosome 8 RING-Type E3 Ubiquitin Transferase RNF139 E3 Ubiquitin-Protein Ligase RNF139 Patched Related Protein Translocated In Renal Cancer Multiple Membrane Spanning Receptor TRC8 RING Finger Protein 139 EC 2.3.2.27
Location (GRCh38)
8:124474866-124488618
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007218.4
Sequence length
3199.0 nt
GC content
0.4054

Transcripts

ID Sequence Length GC content
NM_007218.4 NCBI
AGAGACCUCCUGGGGAGCCGCCGCCGCCGCCCUCUCGGCCAUCGCUGCC… 3199 nt 0.4054
Summary

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

Forensic Context

A longitudinal mRNA expression analysis in post-mortem human blood samples identified the RNF139 as a protein-coding gene involved in protein demannosylation that shows an up-regulated expression pattern after death [Antiga et al. DOI:10.1038/s41598-021-96095-z].