Basic Information

Symbol
RNF185
RNA class
mRNA
Alias
Ring Finger Protein 185 E3 Ubiquitin-Protein Ligase RNF185 FLJ38628 RING-Type E3 Ubiquitin Transferase RNF185 Hypothetical Protein FLJ38628 RING Finger Protein 185 BSK65-MONO1 BSK65-MONO2 BSK65-PANC1 BSK65-PANC2 BSK65-TEST1 BSK65-TEST2 BSK65-TEST3 EC 2.3.2.27
Location (GRCh38)
22:31160158-31207019
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_152267.4
Sequence length
3182.0 nt
GC content
0.4987

Transcripts

ID Sequence Length GC content
NM_001135825.2 NCBI
AUGUGACUGGAGUCCGCGUAGGAGGGGUCGGAGGUCUUACCCAACAGAU… 3014 nt 0.4940
NM_152267.4 NCBI
AUGUGACUGGAGUCCGCGUAGGAGGGGUCGGAGGUCUUACCCAACAGAU… 3182 nt 0.4987
Summary

Enables ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in several processes, including positive regulation of ERAD pathway; protein ubiquitination; and proteolysis involved in protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the RNF185 in microglia, where it is involved in the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].