Basic Information

Symbol
RNF19A
RNA class
mRNA
Alias
Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase Dorfin RNF19 Ring Finger Protein 19A, E3 Ubiquitin Protein Ligase E3 Ubiquitin-Protein Ligase RNF19A Double Ring-Finger Protein DKFZp566B1346 Protein P38 Interacting With Transcription Factor Sp1 Ring-IBR-Ring Domain Containing Protein Dorfin Ring Finger Protein 19A RING Finger Protein 19A Ring Finger Protein 19 EC 2.3.2.31 EC 6.3.2 P38
Location (GRCh38)
8:100257059-100336218
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_183419.4
Sequence length
4186.0 nt
GC content
0.3939

Transcripts

ID Sequence Length GC content
NM_001280539.2 NCBI
CUCUUCUCUCAUUGGCACUGCCUGUCUACUGCCGAGGGCAUUUGAGUGU… 4278 nt 0.3915
NM_001353837.2 NCBI
CUUUUAAACUUAGAUUUUAAACUAUCUCUGUCACUUUAGAAACCCAAGU… 5765 nt 0.3877
NM_001353838.2 NCBI
GCAAAUUUGGAGCCGGGACAUCGCCCCGCAAGCCGUGCUGCCUGGGGCC… 4177 nt 0.3926
NM_015435.5 NCBI
AUAGUCACCAGAAGCUGGAAGAGUCAAAGGACACAUUCUCCCCUCAAGC… 4323 nt 0.3963
NM_183419.4 NCBI
GCGCUUCCUCAGGCUGCUGUCGCCGCUGCUGGGAGAUGGGCCUACUCGC… 4186 nt 0.3939
Summary

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Forensic Context

A study in mice demonstrated that the RNF19A gene, identified as RNF19 (ring finger protein 19), was upregulated in common in spleen leukocytes across three distinct models of systemic inflammation and injury (trauma/hemorrhage, burn injury, and LPS infusion) at a 2-hour post-injury time point. This upregulation was part of a common early transcriptional response involving pathways related to cell death, and the differential expression of this and other genes was validated by RT-PCR, showing good correspondence with microarray findings [Brownstein et al. DOI:10.1152/physiolgenomics.00213.2005].