Basic Information

Symbol
RNF220
RNA class
mRNA
Alias
Ring Finger Protein 220 C1orf164 RING-Type E3 Ubiquitin Transferase RNF220 E3 Ubiquitin-Protein Ligase RNF220 FLJ10597 Chromosome 1 Open Reading Frame 164 RING Finger Protein 220 EC 2.3.2.27 HLD23
Location (GRCh38)
1:44405185-44651724
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018150.4
Sequence length
3042.0 nt
GC content
0.5572

Transcripts

ID Sequence Length GC content
NM_001319956.1 NCBI
AGUGCCUGUAUGUGUGUGAGUGUGAGAGAAUGUGUGCGUGCGUGUGUGU… 3149 nt 0.5557
NM_001319957.2 NCBI
CUCUUAUCUUCAUCAUCGCUCUACAUCCACGAACAUUUCCUGAGCUCCU… 2241 nt 0.5493
NM_001376486.1 NCBI
AUUCACUGAUUAGAUCCAGCGCUGAGAGGCAGCACUGCUCCUUCUCUCA… 3120 nt 0.5577
NM_001376487.1 NCBI
AUUCACUGAUUAGAUCCAGCGCUGAGAGGCAGCACUGCUCCUUCUCUCA… 3116 nt 0.5578
NM_001376488.1 NCBI
GGAGAGCUUCCGUGUGGCCCCCCGGGCGAGGCCGCCCACGGUGGUGAGG… 3056 nt 0.5658
NM_001376489.1 NCBI
AGGGCCAACAUGGCCGCCGCCGCCGCUUGGAGCUGAAGUGCCGCCGCCG… 2062 nt 0.5820
NM_018150.4 NCBI
AUUCACUGAUUAGAUCCAGCGCUGAGAGGCAGCACUGCUCCUUCUCUCA… 3042 nt 0.5572
Summary

Enables beta-catenin binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and protein monoubiquitination. Located in nuclear lamina and nucleoplasm. Part of protein-containing complex. Implicated in hypomyelinating leukodystrophy 23. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the RNF220 is a previously reported circular RNA (circRNA) [Memczak et al. DOI:10.1038/nature11928]. A study in human patients with heart failure after acute myocardial infarction demonstrated that the RNF220 was significantly upregulated in peripheral blood mononuclear cells from individuals exhibiting sacubitril/valsartan resistance compared to non-resistant patients, as validated by quantitative real-time PCR in 18 sample pairs [Su et al. DOI:10.1016/j.ejphar.2023.175547].