Basic Information

Symbol
RNF5
RNA class
mRNA
Alias
Ring Finger Protein 5 RMA1 RING5 NG2 G16 Ring Finger Protein 5, E3 Ubiquitin Protein Ligase E3 Ubiquitin-Protein Ligase RNF5 Ram1 Homolog RING-Type E3 Ubiquitin Transferase RNF5 RING Finger Protein 5 Protein G16 EC 2.3.2.27 HsRma1
Location (GRCh38)
6:32178405-32180793
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006913.4
Sequence length
1117.0 nt
GC content
0.5354

Transcripts

ID Sequence Length GC content
NM_006913.4 NCBI
GAAGCCUGCCCAACGAUCGUGGGCAGGAGGUGGUUUCUGGUUUGUUGGG… 1117 nt 0.5354
Summary

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the RNF5 was downregulated in ileum tissue from methamphetamine-treated animals compared to saline-treated controls and is located near SNPs associated with inflammatory bowel disease [Sun et al. DOI:10.21037/Atm-20-7741]. A study in mice demonstrated that the RNF5 mRNA was positively correlated with miR-21 levels in all subjects [Miguel-Hidalgo et al. DOI:10.1016/J.Pnpbp.2017.08.009].