Basic Information

Symbol
RNF7
RNA class
mRNA
Alias
Ring Finger Protein 7 CKBBP1 ROC2 RBX2 SAG Regulator Of Cullins 2 RING-Box Protein 2 Sensitive To Apoptosis Zinc RING Finger Protein SAG Sensitive To Apoptosis Gene Protein CKII Beta-Binding Protein 1 Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2 Zinc RING Finger Protein SAG RING Finger Protein 7 EC 2.3.2.27 EC 2.3.2.32 Rbx2
Location (GRCh38)
3:141738249-141747560
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014245.5
Sequence length
2669.0 nt
GC content
0.4016

Transcripts

ID Sequence Length GC content
NM_001201370.2 NCBI
CUUCCCCAAGCCAACGUCUCCGCCGUCGGCUCCGCGGCGCCGCCAUGGC… 2621 nt 0.4014
NM_014245.5 NCBI
CUUCCCCAAGCCAACGUCUCCGCCGUCGGCUCCGCGGCGCCGCCAUGGC… 2669 nt 0.4016
NM_183237.3 NCBI
CUUCCCCAAGCCAACGUCUCCGCCGUCGGCUCCGCGGCGCCGCCAUGGC… 2662 nt 0.4012
Summary

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the RNF7 in microglia, implicating it within the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].