Basic Information

Symbol
ATP6V0C
RNA class
mRNA
Alias
ATPase H+ Transporting V0 Subunit C ATP6C ATP6L VATL Vma3 ATPL ATPase, H+ Transporting, Lysosomal 16kDa, V0 Subunit C V-Type Proton ATPase 16 KDa Proteolipid Subunit C Vacuolar Proton Pump 16 KDa Proteolipid Subunit C V-ATPase 16 KDa Proteolipid Subunit C ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 16kD H(+)-Transporting Two-Sector ATPase, 16 KDa Subunit Vacuolar ATP Synthase 16 KDa Proteolipid Subunit V-Type Proton ATPase 16 KDa Proteolipid Subunit Vacuolar Proton Pump 16 KDa Proteolipid Subunit Vacuolar H+ ATPase Proton Channel Subunit V-ATPase 16 KDa Proteolipid Subunit V-ATPase Subunit C EPEO3 VPPC
Location (GRCh38)
16:2513713-2520218
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001694.4
Sequence length
1093.0 nt
GC content
0.6295

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-403.50 kcal/mol
Thermodynamic ensemble
Free energy: -424.30 kcal/mol
Frequency: 0.0000
Diversity: 353.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((.((((((.....(((.((.(.(((.((((((((((...((....)).((.....))..(((........)))))))))))))...))).).))))).......)))..))))))))))))((((.............)))).((((((((((..(((.((.(((((((((.((((((........(((......)))((.(((((((((((((((..(((.(((...((.(((((((.((((...)))))).))))).))))).))).)))))))........)))))))).))((((((((((......(((((.(((((((.(((.((((......)))).))).))))(((((((((......))))))))).......(((((((((((((.((...(((((((((...(((.((..(((((((((((((.(.(.((((.((((.((((((((((((((...((((...))))..((.((((..(((((...((((....)))))))))..)))).)).....(((((((((((.(((.......(((..((...((.((((((.......((((((..........................).)))))....))))))))....))...)))....(((((((((((((.............(((..........)))..((.(((....(((((....)))))..)))))))))))).))))))..))).)))...))))))))...........)))))..)))).((((..((.....)).))))......)))))..))))..))))).)))))))...)))))))......)).))).))))).)))).)).))))........)))))))))......))))))))....)))))...)))))((((.(((((.((....)))))))))))..........(((((..........))))).))))))...)))).))))).)).)))....(((((..((((((.(((.....((..(((.(((((...))))).)))..))))).))))))...))))))))))))))).
Thermodynamic Ensemble Prediction
(((((((((.((((({.....(((.((.(.(((.((((((((((..,((....||.{,.,...}}..||,.......}))}))))))))))...))).).))))).,,....)},.,)))))))))))),{{{.............}|}|.({{{{{((,(((((,(((((((,.{(((.,,{,,,||.....,}|}}}}.}}))}|{,{,((({(((((((,{..((({(((...||}||||{||,||||...)))}}}.}}||}.||}||,,}|||||}}||,,.,,,,.}|||}}||{||{((((((({{......((({{{(((((((.(((.((((......)))).))).))))(((((((({......})))))))).......{(((((((({(((.((...(((((((((...(((.{(..(((((((((((((.(.(.((((.((((.(((((((({{{{((,..,|{|...|||{..((.((((,,(({((,{,(((({{{,},||}}})}.{||||{|,...}}|,||||,{{{..,{{,...,,,,....((.{.((.((((((.......(((((,...,,.....................).)))))....))))))}).,,.}}.,,|}}....,{(({{{((((({.............(((..,,,...{,|||,,,,.,,{{{,.(((((....)))))..)},),))))))).))))))}}}})})))...)}))}},}))))}),.,,,))}))..)))).|||},|||,..,})}})}))....,,))))),.)))}..))))).)))))))..,)))))))......}}.))).))))).)))).)),)})),,......)))))))))......}}}))}}}...,}}}}),,,)))))((((.(((((.((....)))))))))))...,,{{{..((({(........,,}}||},}}|.},,}||,,)}}))),,},,},))))}|||{,..((((((.(({....,((..(((.(((((...))))).)))..))))).))))))...,,))}}))))))})).

Transcripts

ID Sequence Length GC content
NM_001198569.2 NCBI
CCAACGCUGCGGAGAUCCAGAGGCCGGCGGCGCCCGGAAACACCCGCGG… 1016 nt 0.6201
NM_001694.4 NCBI
GUUCUGCGGUGCUGGUAUUUAGAGCGCAGCGGCUGACGGGCCGGAUCGC… 1093 nt 0.6295
Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Forensic Context

No relevant information is available at the moment.